Young mice expel the tapeworm Hymenolepis diminuta and are protected from colitis by triggering a memory response with worm antigen

Thymus dependence of tapeworm (Hymenolepis diminuta) elimination from mice.

Although normal mice eliminated the lumen-dwelling intestinal cestode Hymenolepis diminuta by day 21 post-cysticercoid inoculation, congenitally thymus-deficient (nude) mice maintained their work burdens. Nude mice grafted with thymus glands or injected with thymus cells eliminated their worms.

Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice.

Analysis of parasite-host interactions can reveal the intricacies of immunity and identify ways to modulate immunopathological reactions. We assessed the ability of a phosphate-buffered saline-soluble extract of adult Hymenolepis diminuta to suppress macrophage (human THP-1 cell line, murine peritoneal macrophages) activity in vitro and the impact of treating mice with this extract on colitis i...

Identification of an NAD-dependent 3-acetamidobenzamide-sensitive system in oncospheres from the tapeworm Hymenolepis diminuta.

( a ) Autoradiograph of RNA species which arise in a transcription reaction. Nomenclature, fragment sizes and experimental conditions are as in 141. RNA circles are arrowed wth their tentative sizes in nucleotides. Precursor (p), ribozyme (IVS), ligated exons (SE3E) and precursor in which the downstream exon has been hydrolysed (5EI) are depicted. ( b ) Autoradiograph of radiolabelled amplified...

New Data on Human Macrophages Polarization by Hymenolepis diminuta Tapeworm—An In Vitro Study

Helminths and their products can suppress the host immune response to escape host defense mechanisms and establish chronic infections. Current studies indicate that macrophages play a key role in the immune response to pathogen invasion. They can be polarized into two distinct phenotypes: M1 and M2. The present paper examines the impact of the adult Hymenolepis diminuta (HD) tapeworm and its ex...

Studies on Malic Enzyme from Hymenolepis Diminuta